When you arrive in Venice, head to St. Mark's Square. Step into St. Mark's Basillica, get a bird's eye view of the city from the clock tower, and visit Doges Palace - arguably Venice's most famous building. From here, you can wander through the many narrow streets filled with family owned shops, hidden restaurants and colorful people. St. Mark's is also the jumping off point for exploring the smaller islands of Venice, including Murano, home of the famous Murano glass.
If art is what you are after, check out the Peggy Guggenheim Collection and the Academy Gallery. Other popular sights include: